/ O f) D. w6 }4 l2 L8 @5 a( h7 h9 [ 不過，如前所述，校正臨床-病理特徵、治療與醫院類型之後進行分析時，對宏觀型疾病來說，相較於SLNB併用完整 ALND，單用SLNB治療傾向有不佳結果，但是沒有顯著差異。+ S! C1 I7 z4 B- I% E N
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美國外科醫師學會住院醫師計畫臨床獎學金、西北大學Feinberg 醫學院外科支持本研究。TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。9 s7 c8 w( |' m e! J. t
TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。" l% n5 X5 H% \
J Clin Oncol. 印刷前線上登載於2009年4月13日。: `) b+ M$ W. x: a' ^1 X
TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。! C% ^$ J: `& h
When Sentinel Lymph Node Biopsy is Enough in Breast Cancer* R" ?, b* u X" i5 `
( T% o7 V0 [! f. Q/ l& }+ F7 Y# stvb now,tvbnow,bttvbBy Nick Mulcahy 4 ^3 r; U" W+ M6 I4 _公仔箱論壇Medscape Medical News 0 |3 M0 I% X( s! V/ G# s8 d " a. f* W) v* }# b1 qMay 19, 2009 — It's a common dilemma for clinicians and their patients with breast cancer: whether or not to perform completion axillary dissection after nodal metastases have been identified by sentinel lymph node biopsy (SLNB).公仔箱論壇 @! ]& r1 c0 S: r+ C; _
! v* w( d) [3 _: m0 ]* T$ j% FTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。A new observational study of 22,278 women suggests that the answer is frequently no, especially if the nodal metastases are microscopic. The study was published online April 13 in the Journal of Clinical Oncology.tvb now,tvbnow,bttvb: v8 b6 X$ m x* x$ s! L Q
. P+ U9 \% e+ l3 `. P. i; OA full axillary dissection may not be necessary for most patients.www3.tvboxnow.com7 I2 b: j H- B G( T
3 ]0 Q9 y5 ^' s"A full axillary dissection may not be necessary for most patients," senior study author David J. Winchester, MD, told Medscape Oncology. Dr. Winchester is chief of the Division of General Surgery and Surgical Oncology at NorthShore University HealthSystem in Evanston, Illinois. # i- t: e( N1 k6 D + D0 h' r1 v9 a* e: w. Q m公仔箱論壇He explained that, in the study, completion axillary lymph node dissection (ALND) did not improve outcomes in either axillary recurrence or survival for patients with microscopic disease. Furthermore, there may only be a small benefit with regard to those outcomes with completion ALND for those with macroscopic disease, he suggested.公仔箱論壇6 @0 D$ F! q% t! \2 P5 i. z5 ~+ t3 @: P
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In patients with macroscopic nodal metastases, axillary recurrence and survival were comparable between the 2 treatment groups.TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。" h6 r6 }1 j$ {' `" z- ~- Q. X, S
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However, after the analysis was adjusted for differences between the 2 groups, there was a nonsignificant trend toward better outcomes for completion ALND than for SLNB alone — hazard ratio for axillary recurrence was 0.58 (95% confidence interval [CI], 0.32 - 1.06) and for overall survival was 0.89 (95% CI, 0.76 - 1.04), Dr. Winchester and colleagues report.TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。4 C2 g: B' z5 q I' r% z! Y# Z
/ y0 y. |- b* e, P4 J# G, H公仔箱論壇Still, the study results should cause clinicians to not automatically use completion ALND, noted Dr. Winchester.tvb now,tvbnow,bttvb6 P4 R. q7 f8 T: r& I! b6 k
; c% J2 K9 O7 ?/ K公仔箱論壇We have relied upon that operation too much. & ]' c' b- V/ uwww3.tvboxnow.comtvb now,tvbnow,bttvb* m3 ?" i, y: K1 m9 L1 H
"We have relied upon that operation too much, and this paper points out that we may not need to do it in terms of a survival difference or a regional recurrence difference. This is an operation associated with significant morbidity," he said in a statement.TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。: x5 a, }% c5 K q+ e' F
3 g" Z( ` w$ b& _0 X3 a1 qFor instance, the risk for edema is 30% to 40% with completion ALND, and 2% to 5% with SLNB, he said.3 ^6 j" i* l: @5 U9 E# c! }
) { W+ n! L6 P: |0 otvb now,tvbnow,bttvbThe need for completion ALND has been debated for some time, and led to theAmerican College of Surgeons Oncology Group (ACOSOG) Z0011 trial comparing the 2 approaches, say the study authors. However, the trial was suspended after 5 years, in 2004, due to low patient accrual. % T! a* z V: |$ J9 ntvb now,tvbnow,bttvb 8 n0 p) U0 l$ aTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。An ad hoc analysis of ACOSOG Z0011 showed that 69% of node-positive patients who refused to enroll went on to undergo completion ALND, Dr. Winchester and coauthors comment. They also say if there is ever another prospective clinical trial comparing the 2 approaches, then the current study's results could provide some "equipoise" for random assignment to SNLB alone. ( L+ B& f/ o# e) g. W2 fTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。 0 M4 V& F1 I0 @: k( @www3.tvboxnow.comShift in Practice. X" S& ?: x7 _# T! C9 N9 G
5 r. Y8 r5 u( N( oTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。Dr. Winchester and colleagues used data obtained from the National Cancer Data Base on women with clinically node-negative breast cancer who underwent SLNB and who had nodal metastases from 1998 to 2005 (n?= 97,314). , @; f% O/ h& f2 g4 s7 ]7 k ! G# _ Q$ x9 h, q& v" }: a' L1 f' u公仔箱論壇In addition to evaluating outcomes in these women, the investigators of the new study tallied the proportion of patients undergoing SLNB and completion ALND. 1 z, J# s: ^2 K; E$ JTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。 7 ?* r+ W1 M+ j, W4 V- U1 mThe results indicate that there has been a shift in practice patterns concerning the procedures.公仔箱論壇; y3 T7 A/ {# A; X {7 t
. O) Y3 i! v. [- T6 k"For microscopic nodal disease from 1998 to 2005, the proportion of patients undergoing [SLNB] alone without a completion nodal dissection increased considerably, from about 25% to 45%, whereas for patients with more substantial nodal metastases (the macroscopic group), the proportion stayed fairly constant over the time course of the study," said study lead author Karl Bilimoria, MD, MS, in a statement. He was an American College of Surgeons Research Fellow at the time the analysis was performed, and is now a surgical resident at the Feinberg School of Medicine of Northwestern University in Evanston, Illinois.www3.tvboxnow.com9 [( V8 u; A) ]! Y2 z+ K
4 i- A+ d/ X: G/ Q0 wTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。Specifically, the proportion of patients who underwent SLNB alone for macroscopic disease declined during the study period, from 24.2% to 16.7%; (P?< .001); however, the proportion of patients who underwent SLNB alone for microscopic metastases increased, from 24.7% to 45.3% (P?< .001). ! h0 b6 o1 C9 ZTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。. z4 G* ], f5 O+ @' s. D
Dr. Bilimoria speculated that the increase in the use of SNLB alone for microscopic disease arose as physicians "anecdotally found that nodal dissection is not necessary in all patients." . v6 Z: C) k1 R: z: S8 _& {$ Rtvb now,tvbnow,bttvb4 p$ L0 \9 m0 V, d; F6 k
Outcomes Data in Further Detail B$ o. J4 |& c6 a8 S4 I* Etvb now,tvbnow,bttvbwww3.tvboxnow.com( s& V* ]" V9 }3 A) S {! l* h( n
Because there was a limited number of women with 5-year follow-up in the database, the outcomes analysis comprised a smaller group of women (n?= 22,278) and was limited to the years 1998 to 2000. The group had a median follow-up of 63 months.tvb now,tvbnow,bttvb4 {( W3 t( P2 q. y& W2 `1 p; l
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In patients with microscopic nodal metastases (n?= 2203), there was not a significant difference in outcomes between SLNB alone (5 or fewer nodes) and SLNB with completion ALND (9 or more nodes) — either unadjusted or adjusted for differences in clinico-pathologic characteristics, treatment, and hospital type. 0 q+ R$ C, _8 } p9 zTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。 8 \$ F8 l' R5 }; M% R% u/ U0 TTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。In patients with macroscopic nodal metastases (n?= 20,075), on univariate analysis, there was not a significant difference in outcomes between SLNB alone and SLNB with completion ALND (1.0% vs1.2% [P = .40] for axillary recurrence, 98.5% vs98.2% [P?= .72] for relative survival, and 82.1% vs81.8% [P?= .55] for observed survival).公仔箱論壇/ U% _+ q k* O: H" |* ^
0 G& i6 W* f. P7 M$ T" C) z5 B0 GTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。However, as noted above, after the analysis was adjusted for differences in clinico-pathologic characteristics, treatment, and hospital type, there was a nonsignificant trend toward worse outcomes with SLNB alone than with SLNB with completion ALND for macroscopic disease., K$ s' m; W- q; t: g: j6 I! ]
5 s5 x' P: m. Jtvb now,tvbnow,bttvbThe study was supported by the American College of Surgeons Clinical Scholars in Residence program and the Department of Surgery, Feinberg School of Medicine, Northwestern University.公仔箱論壇4 ^0 ~8 e! n2 _5 V: A
0 F# ~5 J$ Y% I) _1 D* s0 e4 b# }7 nJ Clin Oncol. Published online before print April, 13 2009.
